Competition for Viagra?

Posted on November 10th, 2007 by ofecymagi.
Categories: Erectile Dysfunction Drugs, Erectile dysfunction pills.

Jan. 2, 2001 — There’s no doubt about it: Viagra is one of the most popular and best-selling drugs ever to hit the pharmacy. Since it first appeared on the market in 1998, more than 20 million prescriptions have been written for it. But while countless men have bade farewell to impotence or erectile generic viagra side effects, others have found that Viagra does not work well for them. For these men, good news may be on the way, as researchers have discovered yet another promising treatment for sexual dysfunction.

“Many different types of treatments exist for men with erectile difficulties,” says Craig Niederberger, MD, FACS, who explains that much of Viagra’s popularity is credited to the fact that it can be taken as a pill.

Other treatments, he adds, are less convenient and may involve injection of medication directly into the penis. Niederberger, who was not involved in the recent research, is chief of the division of andrology at the University of Illinois, in Chicago.

“Traditionally, treatments for erectile dysfunction have focused on the processes that turn on smooth muscle relaxation and produce erection, rather than by blocking the dysfunction erectile meds of smooth muscle,” says study author Christopher J. Wingard, MS, PhD. In their study, which appears in the January issue of Nature Medicine, Wingard and his colleagues looked at the latter process.

When men are sexually aroused, blood flow into the penis increases, filling up spongy cylinders called corpora cavernosa. When the cylinders fill with blood, the penis hardens and becomes erect. Acting like flood gates, muscular blood vessels called arterioles control the flow of blood into the penis. A chemical called nitric oxide is a signal for the gates to open, and Viagra works by increasing the amount of nitric oxide, signaling the gates to open and increasing the blood flow.

Researchers from the Medical College of Georgia, in Augusta decided to explore a different approach. They found that an enzyme called Rho-kinase is present in the spongy cylinders. Elsewhere, this enzyme enhances the activity of muscle, like the muscle in those flood gate muscular vessels. The researchers reasoned that if they inhibited the activity of this enzyme, the muscle would relax, opening the flood gates.

Sure enough, it worked. They injected a drug called Y-27632, a known inhibitor of Rho-kinase, into the spongy cylinders of rats, causing penile erections. In further testing, they showed that the Rho-kinase inhibition worked completely independently of the way Viagra works.

It’s estimated that about half of all American men between the ages of 40 and 70 are affected with impotence to some degree, and the underlying causes vary. Sometimes, psychological reasons or lifestyle factors, such as excessive alcohol article drug dysfunction erectile from internal medicine news rx update, can lead to impotence. However, a persistent problem is usually due to a chronic illness or a side effect of certain drugs.

“Viagra has proven effective in 60-70% of the general population and only about 40% effective in specific groups like diabetics who have some form of erectile dysfunction,” says Wingard. “Thus, it appears that we have a new angle on developing a citrate generic sildenafil viagra treatment of erectile dysfunction that does not rely on the action of the nitric oxide pathway.”

“The type of drug studied in this article uses an entirely new pathway to cause erections in animals, and opens the door to many new possible drugs,” says Niederberger. “If the studied drug is used in the future, it may add to the list of drugs used in direct injection.”

So, while the need exists for a wider range of therapies, and the news of this research is encouraging, it is still too early to tell whether Y-27632 will sit beside Viagra on the shelves of the local pharmacy.

While this work examined an injectable form of Y-27632, says Wingard, current research efforts have been focusing on using it in a topical form. If this method proves a viable means of administering the compound, he says, “It could lead the way for the development of a new drug treatment of erectile dysfunction.”

The study was supported by grants from the National Institutes of Health, the American Heart Association, and the American Health Assistance Foundation.

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Eat, Exercise, Relax, and Sleep Your Way to Better Sex

Posted on November 2nd, 2007 by ofecymagi.
Categories: Erectile Dysfunction Drugs, Erectile dysfunction pills.



Thought about leading a healthier lifestyle but haven’t gotten
around to doing it? Here’s a possible incentive: Experts say people who are
mentally and physically fit are more likely to have good sex lives.

“If you feel good about yourself, you are in a better
position to feel good about relationships, including your sex life,” says
Karen Zager, PhD, a psychologist in private practice in New York City.

“When one is not feeling well, and is exhausted, it can
certainly have a negative impact on the quality of one’s sex life,” says
Saralyn Mark, MD, a senior medical adviser at the Office on Women’s Health.

This may all seem intuitive, yet many people find the road to a
fitter mind and body to be bumpy, especially if it involves losing weight,
starting an exercise program, reducing stress, or getting enough sleep.

One big reward, though, is to look and feel better — arguably
a plus for good romantic and sensual activities.

Eat Right

While there is no proven connection between a balanced diet and
bedroom performance, a poor diet can cause health problems that can possibly
interfere with sex.

Studies show animals that get too few calories tend to have
weakened immune systems, says John Allred, PhD, professor emeritus of nutrition
at Ohio State University. He says illness can be a big hurdle for pleasurable
erectile dysfunction home remedy.

“If you have heart disease, then you might be taking
medication that would inhibit sexual activity, or you might be afraid to have a
heart attack,” says Allred. “If you have the flu, a high fever, or just
don’t feel good … any of these things would be a turn-off.”

Mark Kantor, PhD, associate professor of nutrition and food
science at the University of Maryland, agrees, saying, “You will feel sexy
if you look and feel good.”

A way to do that is to eat an overall balanced diet and to
exercise each day. The two go hand-in-hand, says Kantor, as demonstrated by
today’s obesity problem, in which people eat too much food and aren’t active
enough.

Move That Body

Being physically active can be a natural Viagra boost,
according to the American Council on Exercise (ACE), which recommends 20 to 30
minutes of moderate exertion a day.

“Men and women who exercise regularly are going to have
increased levels of desire,” says Cedric Bryant, PhD, ACE’s chief exercise
physiologist. “They’re going to have enhanced confidence, enhanced ability
to achieve orgasm, and greater sexual herbal erectile dysfunction treatment.”

If that isn’t motivation enough to work out, consider this:
Researchers have found that there is a correlation between waist size and a
man’s odds of having erectile dysfunction (ED). The larger the man’s waist
size, the greater his chance of having ED (because of a higher risk of
underlying de gmx impotence disease).

Need more positive reinforcement? Studies show that regular,
moderate exercise can have a positive benefit on major sexual problems, such as
ED in men and low libido in both men and women.

It only makes sense, say experts, since ED is often caused by
poor blood flow to the penis, and exercise can improve the body’s ability to
pump and circulate blood throughout the body.

The same can be true for the ladies. In one University of Texas
at Austin study, physically active women who watched an X-rated film had a 169%
greater blood flow to the vagina compared with when they were inactive.

And there’s more good news. Mark says exercise can promote the
body’s release of hormones important for sexual arousal, increase aerobic
capacity and muscle strength, and boost self-body image — all definite
benefits for between-the-sheets play.

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Type 2 Diabetes: Living With Complications - Home Treatment

Posted on October 31st, 2007 by .
Categories: Erectile Dysfunction Drugs, Erectile dysfunction pills.

Source Type 2 Diabetes: Living With Complications - Home Treatment article
type 2 diabetes. Eating a balanced diet, getting
regular exercise, taking oral diabetes medication, and possibly taking insulin
to keep your blood sugar levels within a
normal or near-normal range will help you feel better
and have control of your life. If you need help with these skills, see the
topic
Type 2 Diabetes: Living With the Disease.

Early treatment of complications can help save your vision, slow
the rate of kidney failure, and reduce the risk of amputation. Keep all
appointments with your doctor, specialists, and other health professionals. The
examinations and tests done during these visits can detect early signs of
complications and monitor the progression of existing complications.

Take the following measures at home to help control
complications.

Heart and large blood vessel disease (macrovascular disease)

  • Don’t smoke.
    Smoking increases your risk for heart
    attack.
  • If you are age 30 or older, take a low-dose, or baby,
    aspirin daily if advised by your health professional.
  • Take your
    blood pressure medicine, as prescribed.

Eye disease (diabetic retinopathy)

Call your
ophthalmologist or
optometrist if you notice any changes in your vision.
Early detection and treatment of any changes can help prevent vision
loss.

Avoid heavy lifting if you have advanced diabetic eye disease
(proliferative retinopathy).

Call your ophthalmologist if you have retinopathy and become
pregnant. Retinopathy can become worse rapidly during pregnancy.

If you have severe vision loss from diabetic retinopathy,
vision aids can help you do as much of your diabetes
care as possible. These include home glucose monitors with large-print displays
and talking glucose monitors. Your local or state organization for the visually
impaired can help you find appropriate vision aids.

For more help, see the topic
Diabetic Retinopathy.

Kidney disease (diabetic nephropathy)

  • Take your blood pressure medications, if
    prescribed. Your blood pressure should be 130/80 millimeters of mercury (mm Hg)
    or lower.
  • Get no more than 10% of your daily calories from
    protein.
  • Limit salt in your diet, because it makes your body retain
    fluid and can increase your blood pressure.
  • Avoid
    nonsteroidal anti-inflammatory drugs (NSAIDs),
    including ibuprofen (such as Advil or Motrin), ketoprofen, and
    naproxen (such as Aleve). These medications can harm your kidneys.

For more help, see the topic
Diabetic Nephropathy.

Foot problems

Foot care is important for people with diabetes. You need to
inspect your feet every day and protect them from injury. If you have poor
eyesight, have someone else check your feet.

To protect your feet:

  • Avoid exercise that could injure your feet;
    walking is fine, but jogging may be too rough.
  • Make sure bathwater
    is not too hot.
  • Check your shoes for any loose objects or rough
    edges before you put them on.
  • Get early treatment for any foot
    problem, even a minor one. Call your doctor at the first sign of a problem with
    your feet. Blisters, small cuts, or other problems that may seem minor can
    quickly become more serious.

For more information on protecting your feet, see:

Foot care

Nerve damage (diabetic neuropathy)

If it affects your ability to feel (peripheral
neuropathy):

  • Turn down the temperature of your hot-water
    heater and use a bath thermometer or have someone test your bath water to see
    whether it is too hot.
  • Do not go barefoot, even in the
    house.
  • Do not use an electric blanket.
  • To prevent
    falls, arrange your furniture so that walkways are free of clutter.
  • To avoid burning your hands, use pot holders when you
    cook.

If it affects your body’s internal functioning (autonomic neuropathy):

  • Eat smaller, more frequent meals that contain
    less fat and fiber if you have
    gastroparesis or other digestive
    problems.
  • Drink more fluids each day if you have urinary problems
    or profuse sweating. This will prevent urinary tract infections and
    dehydration.
  • Try a device or medication
    such as Viagra, Levitra, or Cialis for erection problems or a lubricating cream
    for vaginal dryness if you have sexual problems. Check with your doctor to find
    out whether you can take these medications.
  • Check your blood sugar
    level more often if you have
    hypoglycemia unawareness, especially before
    driving.

If it affects one nerve (focal
neuropathy):

  • Wear a joint splint, if your health
    professional advises this.
  • Take breaks when you are doing
    activities that require repetitive movements.
  • Make sure your work
    environment provides appropriate support.

For more help, see the topic
Diabetic Neuropathy.

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